The adverse effects of chemotherapy have resulted in the study of the mechanisms that causes cancer cells to self-destruct. A team of researchers from Tel Aviv University published their findings on Oncotarget. The study found out that three proteins had the ability to kill fast-duplicating cancer cells. Prof. Malka Cohen-Armon from the university’s Sackler School of Medicine, led the research. The researchers found that during mitosis, the three proteins can be specifically modified, thus unleashing of an internal death mechanism that kills the cancer cells.
Speaking after the publishing their successful research, Prof. Cohen-Armin said that the mechanism kills only cancer cells without causing any damage to the healthy cells. He adds that the faster the proliferation of the cancer cells, the more efficient the mechanism in eradicating them. He notes that skillful adoption of this mechanism could be used to treat aggressive cancer. Such types of cancer have previously remained unaffected by the traditional chemotherapy such as breast, lung, colon, blood, brain, pancreas, and ovary cancer. Other members of the research team included Dr. Talia Golan and Prof. Shai Izraeli. The two researchers are from the Cancer Research Center at Sheba Medical Center. In addition, Prof. Tamar Peretz of Hadassah Medical Center’s Sharett Institute of Oncology was also part of the team. Follow Oncotarget on Twitter.
Further, the research found that Phenanthridine derivatives can impair the activities of the three proteins. This situation leads to the distortion of the spindle structure besides inhibiting the segregation of chromosomes. To this end, it sets the cells on the self-destruction path. The rapidness of the process depends on the cancer cell’s replication rate.
Oncotarget is a weekly medical journal that covers different news, researches and studies on all aspects of oncology. The peer-reviewed open access journal went public in 2010. Mikhail Blagosklonny and Andrei V. Gudkov serve as the journal’s editors-in-chiefs. The two scientists have extensive experience in their respective fields of specialization. The publication has continued to receive high ratings. Most medical professionals across the globe continue to rely on it for news on oncology and other science-related subjects. Notably, Oncotarget is published by Impact Journals. Authors are encouraged to submit their papers for peer-review by the journal’s experienced editors. Download output styles at Endnote.com